Parsons P E, Grunstein M M, Fernandez E
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver.
Chest. 1989 Jul;96(1):96-101. doi: 10.1378/chest.96.1.96.
The influence of progressive hypoxia and hypercapnia on respiratory mechanics was evaluated in 26 subjects (six normal subjects, seven asthmatic subjects, seven patients with IPD, and six patients with COPD). During separate rebreathing runs of progressive isocapnic hypoxia and normoxic hypercapnia, breath-to-breath changes in RL and Cdyn were determined. In five of the six normal subjects, seven of the seven asthmatic subjects, and six of the seven subjects with IPD, RL decreased with both progressive hypoxia and hypercapnia without a change in Cdyn. In the patients with COPD, the effects of hypoxia and hypercapnia on RL and Cdyn were variable. Compared to normal subjects, the changes in RL during hypoxia and hypercapnia were not significantly different in the asthmatic subjects and the patients with IPD. These data provide evidence that acute progressive hypoxia and hypercapnia are associated with significant changes in Raw in both normal subjects and patients with chronic pulmonary disease.
在26名受试者（6名正常受试者、7名哮喘患者、7名间质性肺疾病（IPD）患者和6名慢性阻塞性肺疾病（COPD）患者）中评估了进行性低氧血症和高碳酸血症对呼吸力学的影响。在分别进行的进行性等碳酸血症性低氧血症和常氧性高碳酸血症的重复呼吸试验中，测定了气道阻力（RL）和动态顺应性（Cdyn）的逐次变化。在6名正常受试者中的5名、7名哮喘患者中的7名以及7名IPD患者中的6名中，随着进行性低氧血症和高碳酸血症，RL降低而Cdyn无变化。在COPD患者中，低氧血症和高碳酸血症对RL和Cdyn的影响各不相同。与正常受试者相比，哮喘患者和IPD患者在低氧血症和高碳酸血症期间RL的变化无显著差异。这些数据表明，急性进行性低氧血症和高碳酸血症与正常受试者和慢性肺病患者的气道阻力（Raw）的显著变化有关。
