Hutchison A A, Olinsky A
Thorax. 1981 Oct;36(10):759-63. doi: 10.1136/thx.36.10.759.
Three children and two young adults with severe asthma who had frequent episodes of respiratory failure were studied. Isocapnic hypoxia and hyperoxic hypercapnia were produced separately using a rebreathing apparatus. Alveolar carbon dioxide tension and oxygen tension were estimated by continuously sampling expired gases. The three young children had a diminished response to hypoxia but a normal response to hypercapnia when compared to control asthmatic children (p less than 0.05) or healthy children (p less than 0.05). The two young adult patients had a normal response to hypoxia but one had a low response to hypercapnia. Studies of parents of these patients suggested that the chance combination of a possibly familial, inappropriate response to hypoxia with severe asthma would lead to a risk of respiratory failure.
对三名患有严重哮喘且频繁出现呼吸衰竭的儿童和两名年轻成年人进行了研究。使用再呼吸装置分别诱发等碳酸血症性低氧血症和高氧性高碳酸血症。通过持续采集呼出气体来估算肺泡二氧化碳分压和氧分压。与对照哮喘儿童（p<0.05）或健康儿童（p<0.05）相比，这三名幼儿对低氧血症的反应减弱，但对高碳酸血症的反应正常。两名年轻成年患者对低氧血症的反应正常，但其中一人对高碳酸血症的反应较低。对这些患者父母的研究表明，对低氧血症可能存在的家族性不适当反应与严重哮喘的偶然组合会导致呼吸衰竭风险。
