小细胞肺癌和兰伯特-伊顿肌无力综合征在无病生存期13年后复发。

Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period.

作者信息

Asano Fumio, Watanabe Keisuke, Shinkai Masaharu, Tei Yoshitaka, Mishina Kei, Tanabe Mikiko, Ishii Hiroshi, Shinoda Masahiro, Shimokawaji Tadasuke, Kudo Makoto, Kaneko Takeshi

机构信息

Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

出版信息

Chin J Cancer. 2016 Jul 2;35(1):63. doi: 10.1186/s40880-016-0127-x.

DOI:10.1186/s40880-016-0127-x

PMID:27370896

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4930592/

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.

摘要

兰伯特 - 伊顿肌无力综合征（LEMS）是一种副肿瘤综合征，仅有3%的小细胞肺癌（SCLC）患者会出现LEMS。此外，无病生存期（DFS）超过10年的SCLC患者复发情况罕见。我们报告了1例在13年DFS期后SCLC和LEMS均复发的患者。13年前，一名69岁男性被诊断为LEMS和SCLC（cT0N2M0，ⅢA期）。患者接受了放化疗并获得完全缓解。随着抗癌治疗，LEMS症状得到缓解。82岁时，患者出现步态障碍，随后左侧锁骨上淋巴结肿大，进一步检查发现SCLC复发。即使在较长的DFS期后，如果患者出现复发性或继发性副肿瘤性神经综合征，可能仍需仔细筛查SCLC的复发情况。