Kumar Narendra, Khosla Divya, Kumar Ritesh, Mandal Arup K, Saikia Uma N, Kapoor Rakesh, Singh Shrawan K, Sharma Suresh C
Department of Radiotherapy and Oncology, Regional Cancer Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Cancer Res Ther. 2014 Jul-Sep;10(3):571-4. doi: 10.4103/0973-1482.137955.
Urachal carcinoma is a rare malignancy of urogenital tract. The objective of this study was to assess the clinical presentation, histopathological findings, treatment and outcome of patients of urachal carcinoma at a tertiary care centre.
A retrospective analysis of six cases of urachal carcinoma diagnosed over a period of 7 years from 2005 to 2011 was carried out. All pathologic specimens were reviewed by a single pathologist. Clinical and histological features along with treatment were reviewed and patient follow-up and survival outcome was obtained.
The mean age at diagnosis was 36 years. Of the six patients, five were male. The tumor was located in dome in five and dome and anterior wall in one patient. All patients underwent partial cystectomy with bilateral pelvic lymph node dissection. The Sheldon pathologic stage was stage II in 1, IIIA in 2, IVA in 3 cases. Five out of six patients received adjuvant radiotherapy. The mean follow-up period was 37 months. Three out of six were disease free at last follow-up.
Urachal carcinomas are rare and usually locally advanced at presentation with a high risk of distant metastases. Surgery is the primary treatment of choice. Adjuvant therapy may decrease the chances of recurrence but it needs to be elucidated by prospective trials.
脐尿管癌是一种罕见的泌尿生殖道恶性肿瘤。本研究的目的是评估一家三级医疗中心脐尿管癌患者的临床表现、组织病理学发现、治疗方法及预后。
对2005年至2011年7年间诊断的6例脐尿管癌病例进行回顾性分析。所有病理标本均由一名病理学家复查。回顾临床和组织学特征以及治疗方法，并获取患者的随访情况和生存结果。
诊断时的平均年龄为36岁。6例患者中，5例为男性。肿瘤位于脐顶部5例，位于脐顶部和前壁1例。所有患者均接受了膀胱部分切除术及双侧盆腔淋巴结清扫术。谢尔顿病理分期：Ⅱ期1例，ⅢA期2例，ⅣA期3例。6例患者中有5例接受了辅助放疗。平均随访期为37个月。6例患者中有3例在最后一次随访时无疾病复发。
脐尿管癌罕见，通常在就诊时已局部进展，远处转移风险高。手术是主要的治疗选择。辅助治疗可能会降低复发几率，但需要前瞻性试验予以阐明。
