Hicks Kimani D, Sullivan Alana W, Cao Jinyan, Sluzas Emily, Rebuli Meghan, Patisaul Heather B
Department of Psychology, North Carolina State University, Raleigh, NC 27695, USA.
Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA; W. M. Keck Center for Behavioral Biology, Raleigh, NC 27695, USA.
Horm Behav. 2016 Aug;84:121-6. doi: 10.1016/j.yhbeh.2016.06.010. Epub 2016 Jun 30.
Concerns have been raised regarding the potential for endocrine disrupting compounds (EDCs) to alter brain development and behavior. Developmental exposure to bisphenol A (BPA), a ubiquitous EDC, has been linked to altered sociosexual and mood-related behaviors in various animal models and children but effects are inconsistent across laboratories and animal models creating confusion about potential risk in humans. Exposure to endocrine active diets, such as soy, which is rich in phytoestrogens, may contribute to this variability. Here, we tested the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein (GEN; administered as the aglycone genistin (GIN)) on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects. Social and activity levels were unchanged by developmental exposure to BPA but soy diet had sex specific effects including suppressed novelty preference, and open field exploration in females. The data presented here reinforce that environmental factors, including anthropogenic chemical exposure and hormone active diets, can shape complex behaviors and even reverse expected sex differences.
人们对内分泌干扰化合物（EDCs）改变大脑发育和行为的可能性表示担忧。在各种动物模型和儿童中，发育期接触双酚A（BPA，一种普遍存在的EDC）与社会性行为和情绪相关行为的改变有关，但不同实验室和动物模型的结果并不一致，这让人对其对人类的潜在风险感到困惑。接触富含植物雌激素的内分泌活性饮食，如大豆，可能是造成这种差异的原因之一。在此，我们测试了低剂量口服BPA和大豆饮食或单一异黄酮染料木黄酮（GEN；以苷元染料木苷（GIN）形式给药）对大鼠社会性行为的单独和联合影响，并假设大豆会掩盖任何与BPA相关的影响。发育期接触BPA对社交和活动水平没有影响，但大豆饮食具有性别特异性影响，包括抑制雌性大鼠的新奇偏好和旷场探索行为。本文提供的数据进一步证明，包括人为化学物质暴露和激素活性饮食在内的环境因素可以塑造复杂行为，甚至逆转预期的性别差异。
