用于可定制药物释放的分级介孔二氧化硅纳米颗粒。
Hierarchical mesoporous silica nanoparticles for tailorable drug release.
作者信息
Wu Wei, Ye Chenyu, Xiao Hong, Sun Xiaowen, Qu Wenhao, Li Xiuhua, Chen Min, Li Jianshu
机构信息
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China; Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory For Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
出版信息
Int J Pharm. 2016 Sep 10;511(1):65-72. doi: 10.1016/j.ijpharm.2016.06.133. Epub 2016 Jun 29.
In order to modulate the drug release profiles, the hierarchical mesoporous silica nanoparticles (HMSNs) are fabricated by a two-step synthetic process. The HMSNs exhibit uniform spherical morphology with nanoscaled size, well mono-dispersed size distribution, and smooth surface. Because of the hierarchical pore structures with different mesoporous sizes and morphologies (partial open and partial blocked pores), the HMSNs can release the loaded drug in a controlled manner. The hierarchical mesoporous structures directed drug release profiles suggest a feasible strategy to tailor drug release behaviors. Meanwhile, the HMSNs exhibit good biocompatibility. Therefore, the HMSNs having tailorable drug release capacity would be a potential candidate to improve their therapeutic efficiency for drug delivery systems.
为了调控药物释放曲线，采用两步合成法制备了分级介孔二氧化硅纳米颗粒（HMSNs）。HMSNs呈现出均匀的球形形态，具有纳米级尺寸、良好的单分散尺寸分布以及光滑的表面。由于具有不同介孔尺寸和形态的分级孔结构（部分开放孔和部分堵塞孔），HMSNs能够以可控方式释放负载的药物。分级介孔结构指导的药物释放曲线表明了一种定制药物释放行为的可行策略。同时，HMSNs表现出良好的生物相容性。因此，具有可定制药物释放能力的HMSNs将是提高其在药物递送系统中治疗效率的潜在候选者。
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