代偿期肝硬化文盲患者中轻微肝性脑病的发生率
Frequency of minimal hepatic encepalopathy in illeterate patients with compensated cirrhosis.
作者信息
Zuberi Bader Faiyaz, Alvi Haris, Zuberi Faisal Faiyaz, Rasheed Tazeen, Nawaz Zunaira
机构信息
Prof. Bader Faiyaz Zuberi, FCPS. Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Dr. Haris Alvi, FCPS. Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
出版信息
Pak J Med Sci. 2016 May-Jun;32(3):595-8. doi: 10.12669/pjms.323.9655.
OBJECTIVE
To determine frequency of Minimal Hepatic Encephalopathy in illiterate patients with compensated cirrhosis.
METHODS
Illiterate patients with compensated cirrhosis with F4 Score on Shear-wave Elastography were selected for study after informed consent. Sample size was estimated at 106. Selected patients were subjected to two tests for detection of MHE, Number Connection Test A and Block Design Test. Patients taking ≥ 30 seconds were labelled as Positive for MHE.
RESULT
Out of 110 selected patients 10.9% were alcoholics and in 8.2% of patients no hepatic virus infection was detected. HCV was positive in 48.2% patients while HBV was positive in 13.6% of patients. MHE was detected in 72 (65.5%) of patients. Major differences were found in MHE Stage II & III by two tests. Over all BDT detected more cases and gave higher Staging in Stage II & III as compared to NCT-A test.
CONCLUSION
Minimal Hepatic Encephalopathy (MHE) could be detected in illiterate patients using NCT-A and BDT Tests.
目的
确定代偿期肝硬化文盲患者中轻微肝性脑病的发生率。
方法
在获得知情同意后，选取剪切波弹性成像F4评分的代偿期肝硬化文盲患者进行研究。样本量估计为106例。所选患者接受两项检测轻微肝性脑病的测试，即数字连接试验A和积木设计试验。完成测试用时≥30秒的患者被标记为轻微肝性脑病阳性。
结果
在110例所选患者中，10.9%为酗酒者，8.2%的患者未检测到肝病毒感染。48.2%的患者丙型肝炎病毒呈阳性，而13.6%的患者乙型肝炎病毒呈阳性。72例（65.5%）患者检测到轻微肝性脑病。两项测试在轻微肝性脑病II期和III期发现了主要差异。总体而言，与数字连接试验A相比，积木设计试验检测到更多病例，且在II期和III期给出了更高的分期。
结论
使用数字连接试验A和积木设计试验可在文盲患者中检测到轻微肝性脑病。
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