Marine Science Program and Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208, USA.
Marine Science Program and Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208, USA.
Environ Pollut. 2016 Sep;216:806-810. doi: 10.1016/j.envpol.2016.06.050. Epub 2016 Jul 1.
The purpose of this study was to determine the lethal and sublethal effects of the antimicrobial tylosin on natural estuarine phytoplankton communities. Bioassays were used in experimental treatments with final concentrations of 5 to 1000 μg tylosin l(-1). Maximum percent inhibition ranged from 57 to 85% at concentrations of 200-400 μg tylosin l(-1). Half maximum inhibition concentrations of tylosin were ca. 5x lower for small phytoplankton (<20 μm) relative to larger phytoplankton (>20 μm) and suggests that small phytoplankton are more sensitive to tylosin exposure. Sublethal effects occurred at concentrations as low as 5 μg tylosin l(-1). Environmental concentrations of tylosin (e.g., 0.2-3 μg l(-1)) may have a significant sublethal effect that alters the size structure and composition of phytoplankton communities. The results of this study highlight the potential importance of cell size on toxicity responses of estuarine phytoplankton.
本研究旨在确定抗菌药物泰乐菌素对天然河口浮游植物群落的致死和亚致死效应。在实验处理中使用了生物测定法，泰乐菌素的最终浓度为 5 至 1000μg/L。在 200-400μg/L 的浓度下，最大抑制百分比范围为 57%至 85%。泰乐菌素的半最大抑制浓度对于<20μm 的小型浮游植物相对较高 (>20μm)而言约低 5 倍，这表明小型浮游植物对泰乐菌素暴露更为敏感。亚致死效应发生在低至 5μg/L 的泰乐菌素浓度下。泰乐菌素的环境浓度（例如，0.2-3μg/L）可能具有显著的亚致死效应，从而改变浮游植物群落的大小结构和组成。本研究的结果强调了细胞大小对河口浮游植物毒性反应的重要性。
