Howe P R, Rogers P F, Smith R M
Commonwealth Scientific and Industrial Research Organisation, Division of Human Nutrition, Adelaide, Australia.
Hypertension. 1989 Jun;13(6 Pt 1):607-11. doi: 10.1161/01.hyp.13.6.607.
The influence of ethanol (alcohol) consumption on blood pressure during and after the development of hypertension was examined by using spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP). Normotensive Wistar-Kyoto (WKY) rats were also used for comparison. Substituting alcohol (5-20%) for drinking water at 1 month of age retarded the age-dependent rise of blood pressure in all three strains so that, at 7 months, blood pressure measured by a tail-cuff method was 24 mm Hg, 26 mm Hg, and 41 mm Hg lower in the alcohol-treated WKY rats, SHR, and SHRSP, respectively, than in untreated rats. Significant differences in blood pressure were seen in each strain after only 3 months. Withdrawal of alcohol at this stage caused an acute rise of blood pressure then a return to subnormal levels, which persisted for a further 3 months. Administration of 15% alcohol to adult WKY rats and SHR for 2 months had no significant effect on blood pressure. Increasing alcohol content to 20% for a further 2 months prevented rises of blood pressure in both strains. Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.
利用自发性高血压大鼠（SHR）和易中风SHR（SHRSP），研究了乙醇（酒精）摄入对高血压发生期间及之后血压的影响。还使用血压正常的Wistar - Kyoto（WKY）大鼠作为对照。在1月龄时用酒精（5 - 20%）替代饮用水，延缓了所有这三个品系血压随年龄的升高，因此，在7月龄时，用尾套法测量的血压，酒精处理的WKY大鼠、SHR和SHRSP分别比未处理的大鼠低24 mmHg、26 mmHg和41 mmHg。仅在3个月后，每个品系的血压就出现了显著差异。在此阶段停止给予酒精导致血压急性升高，然后恢复到低于正常的水平，并持续另外3个月。给成年WKY大鼠和SHR给予15%酒精2个月对血压没有显著影响。再将酒精含量增加到20%持续2个月可防止两个品系的血压升高。因此，虽然持续饮酒不会降低血压，但它似乎能抵消大鼠高血压的发展。
