Howe P R, Rogers P F, Smith R M
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):273-7. doi: 10.1111/j.1440-1681.1985.tb02646.x.
The influence of chronic alcohol consumption on blood pressure was examined in normotensive Wistar/Kyoto rats (WKY) and in stroke-prone spontaneously hypertensive rats (SHR-SP). Ethanol, administered in drinking water from 5 weeks of age to produce moderate blood alcohol levels, substantially retarded the development of hypertension in SHR-SP and caused a mild reduction of blood pressure in WKY. Alcohol withdrawal caused an acute rise in blood pressure in both strains, followed by a reduction to the subnormal levels previously induced by alcohol treatment. This sustained antihypertensive effect of alcohol was not attributable to reductions of body weight or fluid intake.
研究了长期饮酒对正常血压的Wistar/Kyoto大鼠（WKY）和易中风自发性高血压大鼠（SHR-SP）血压的影响。从5周龄开始通过饮用水给予乙醇以产生适度的血液酒精水平，这显著延缓了SHR-SP高血压的发展，并使WKY的血压轻度降低。戒酒导致两种品系的血压急性升高，随后降至酒精治疗前的低于正常水平。酒精这种持续的降压作用并非归因于体重或液体摄入量的减少。
