Department of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, 215137, Jiangsu, China.
Department of Psychology, Xinghua People's Hospital, Xinghua, 225700, Jiangsu, China.
BMC Psychiatry. 2019 Apr 15;19(1):113. doi: 10.1186/s12888-019-2089-4.
Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on the effect of antipsychotics on the expression levels of CSMD1. This study explored whether a change occurs in the expression of the CSMD1 gene before and after antipsychotic treatment in SCZ patients.
The study population comprised Han Chinese patients from eastern China, including 32 SCZ patients and 48 healthy controls. The expression of CSMD1 before and after treatment in the SCZ group and between the two groups was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR).
The expression levels of the CSMD1 gene in the peripheral blood mononuclear cells (PBMCs) of SCZ patients were lower than those in the healthy controls. The expression levels of the CSMD1 gene in the PBMCs of the SCZ patients after antipsychotic treatment were higher than those in the baseline SCZ patients (all P < 0.05).
Our results showed that the expression levels of CSMD1 are correlated with the development and treatment of SCZ, providing further evidence for the involvement of CSMD1 in SCZ.
精神分裂症（SCZ）是一种遗传性、难治性且具有破坏性的精神疾病。先前的研究表明，CUB 和 sushi 多结构域 1（CSMD1）的变体与 SCZ 具有显著的全基因组关联。然而，关于抗精神病药物对 CSMD1 表达水平的影响的研究较少。本研究探讨了 SCZ 患者在接受抗精神病药物治疗前后 CSMD1 基因的表达是否发生变化。
研究人群包括来自中国东部的汉族患者，包括 32 名 SCZ 患者和 48 名健康对照者。使用实时定量聚合酶链反应（RT-qPCR）分析 SCZ 组治疗前后和两组之间 CSMD1 的表达。
SCZ 患者外周血单个核细胞（PBMCs）中 CSMD1 基因的表达水平低于健康对照组。SCZ 患者在接受抗精神病药物治疗后的 PBMCs 中 CSMD1 基因的表达水平高于基线时的 SCZ 患者（均 P<0.05）。
我们的结果表明，CSMD1 的表达水平与 SCZ 的发展和治疗有关，为 CSMD1 参与 SCZ 提供了进一步的证据。
