Park Yeon Won, Lee Dong-Gi, Choi Jae Duck, Lee Jun Ho
Department of Urology, National Police Hospital, Seoul, Korea.
Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
Int Neurourol J. 2016 Jun;20(2):131-6. doi: 10.5213/inj.1630418.209. Epub 2016 Mar 14.
To investigate the incidence of nitrituria and the relationship between nitrituria and metabolic syndrome (MetS).
Data from the Korean National Health and Nutrition Examination Survey V were used. A total of 19,083 participants were included. The chi-square test, the Mantel-Haenszel extension, logistic regression analysis, and multiple linear regression were used to analyze the data.
A total of 2.0% of the participants had nitrituria. The incidence of nitrituria significantly increased with age (P trend<0.001). In addition, nitrituria in women began to significantly increase in the fifth decade, more than in men, and this difference was maintained in the 60s, 70s, and greater than 70s age groups (P<0.001). After adjusting for confounders, the odds ratio (OR) for nitrituria in the MetS group was significantly increased, as compared to the OR for nitrituria in the group without MetS (MetS: OR, 1.577; 95% confidence interval [CI], 1.134-2.192; P=0.007). The glycosylated hemoglobin of the nitrite positive group was significantly higher than the negative group (adjusted mean ±standard error: 6.108 ±0.081 vs. 5.883±0.065, P<0.001).
An effective health policy for urinary tract infection (UTI) is needed for older age groups and women. Screening or management guidelines for UTI are needed in MetS patients.
探讨亚硝酸盐尿的发生率以及亚硝酸盐尿与代谢综合征（MetS）之间的关系。
使用韩国国家健康与营养检查调查Ⅴ的数据。共纳入19083名参与者。采用卡方检验、Mantel-Haenszel扩展法、逻辑回归分析和多元线性回归对数据进行分析。
共有2.0%的参与者有亚硝酸盐尿。亚硝酸盐尿的发生率随年龄显著增加（P趋势<0.001）。此外，女性亚硝酸盐尿在第五个十年开始显著增加，高于男性，且这种差异在60多岁、70多岁和70岁以上年龄组中持续存在（P<0.001）。在调整混杂因素后，与无MetS组相比，MetS组中亚硝酸盐尿的比值比（OR）显著增加（MetS：OR，1.577；95%置信区间[CI]，1.134 - 2.192；P = 0.007）。亚硝酸盐阳性组的糖化血红蛋白显著高于阴性组（调整后均值±标准误：6.108±0.081对5.883±0.065，P<0.001）。
需要针对老年人群和女性制定有效的尿路感染（UTI）健康政策。MetS患者需要UTI的筛查或管理指南。
