[B细胞系的治疗抗性细胞] - Suppr

[Therapy-resistant cells of the B cell line].

作者信息

Hoyer B F, Dörner T

机构信息

Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

出版信息

Z Rheumatol. 2016 Aug;75(6):556-9. doi: 10.1007/s00393-016-0126-y.

DOI:10.1007/s00393-016-0126-y

PMID:27379736

Abstract

摘要

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本文引用的文献

Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases.

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Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors.

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The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus.

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[Therapy-resistant cells of the B cell line].

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