Rumberger J A, Weiss R M, Feiring A J, Stanford W, Hajduczok Z D, Rezai K, Marcus M L
Department of Internal Medicine, University of Iowa, Iowa City.
J Am Coll Cardiol. 1989 Jul;14(1):119-26. doi: 10.1016/0735-1097(89)90061-2.
The detailed evaluation of regional diastolic filling at multiple ventricular levels in the normal human left ventricle has not previously been reported. Ultrafast computed tomography was used to characterize global and regional early diastolic filling in the left ventricle of 11 normal male volunteers. Regional early diastolic filling data from six distinct ventricular levels (apex to base) were fit to a third-order polynomial curve, and the peak rate of diastolic filling and time of peak filling were determined. Peak filling rate was 259 +/- 17 ml/s (+/- SEM) as a global average, where peak filling rate referenced to end-diastolic volume and stroke volume across the levels examined was 3.78 +/- 0.17 s-1 and 4.83 +/- 0.20 s-1, respectively. Average filling fraction was 39 +/- 1%, and time to peak filling from end-systole was 145 +/- 5 ms. Regional (tomographic) peak filling rates, except for the most apical level examined, were not statistically different across the ventricle. Filling fraction and time to peak filling were remarkably constant from one level to another. However, reference of regional peak filling rate to regional end-diastolic volume demonstrated significant nonuniformity from apex (120% of average for all levels) to base (87% of average for all levels). Peak filling rate referenced to tomographic stroke volume was less variable and not statistically different across the ventricle as a whole.(ABSTRACT TRUNCATED AT 250 WORDS)
此前尚无关于对正常人体左心室多个心室层面的区域舒张期充盈进行详细评估的报道。使用超快速计算机断层扫描对11名正常男性志愿者左心室的整体和区域早期舒张期充盈进行特征描述。将来自六个不同心室层面（从心尖到心底）的区域早期舒张期充盈数据拟合成三阶多项式曲线，并确定舒张期充盈的峰值速率和峰值充盈时间。整体平均峰值充盈速率为259±17 ml/s（±标准误），在此，所检查层面的舒张末期容积和每搏量的峰值充盈速率分别为3.78±0.17 s-1和4.83±0.20 s-1。平均充盈分数为39±1%，从收缩末期到峰值充盈的时间为145±5 ms。除所检查的最心尖层面外，心室各层面的区域（断层扫描）峰值充盈速率无统计学差异。从一个层面到另一个层面，充盈分数和峰值充盈时间非常恒定。然而，将区域峰值充盈速率与区域舒张末期容积相关联时，从心尖（所有层面平均值的120%）到心底（所有层面平均值的87%）显示出显著的不均匀性。与断层扫描每搏量相关的峰值充盈速率变异性较小，整个心室无统计学差异。（摘要截选于250词）
