Lee K J, Southee A E, Bautovich G J, Freedman B, McLaughlin A F, Rossleigh M A, Hutton B F, Morris J G
Department of Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Eur J Nucl Med. 1989;15(3):123-7. doi: 10.1007/BF00254623.
Abnormal left ventricular diastolic function is being increasingly recognised in patients with clinical heart failure and normal systolic function. A simple routine radionuclide measure of diastolic function would therefore be useful. To establish this, the relationship of peak diastolic filling rate (normalized for either end diastolic volume, stroke volume, or peak systolic emptying rate), and heart rate, age, and left ventricular ejection fraction was studied in 64 subjects with normal cardiovascular systems using routine gated heart pool studies. The peak filling rate, when normalized to end diastolic volume, correlated significantly with heart rate, age and left ventricular ejection fraction, whereas normalization to stroke volume correlated significantly to heart rate and age but not to left ventricular ejection fraction. Peak filling rate normalized for peak systolic emptying rate correlated with age only. Multiple regression equations were determined for each of the normalized peak filling rates in order to establish normal ranges for each parameter. When using peak filling rate normalized for end diastolic volume or stroke volume, appropriate allowance must be made for heart rate, age and ejection fraction. Peak filling rate normalized to peak ejection rate is a heart rate independent parameter which allows the performance of the patient's ventricle in diastole to be compared with its systolic function. It may be used in patients with normal systolic function to serially follow diastolic function or if age corrected, to screen for diastolic dysfunction.
临床心力衰竭且收缩功能正常的患者中，左心室舒张功能异常越来越受到关注。因此，一种简单的常规放射性核素舒张功能测量方法将很有用。为了确定这一点，我们使用常规门控心血池研究，在64名心血管系统正常的受试者中，研究了舒张末期充盈率峰值（根据舒张末期容积、每搏量或收缩期排空率峰值进行标准化）与心率、年龄和左心室射血分数之间的关系。当根据舒张末期容积进行标准化时，充盈率峰值与心率、年龄和左心室射血分数显著相关，而根据每搏量进行标准化时，与心率和年龄显著相关，但与左心室射血分数无关。根据收缩期排空率峰值进行标准化的充盈率峰值仅与年龄相关。为每个标准化的充盈率峰值确定了多元回归方程，以建立每个参数的正常范围。当使用根据舒张末期容积或每搏量进行标准化的充盈率峰值时，必须适当考虑心率、年龄和射血分数。根据射血率峰值进行标准化的充盈率峰值是一个与心率无关的参数，它可以将患者心室的舒张功能与其收缩功能进行比较。它可用于收缩功能正常的患者，以连续跟踪舒张功能，或者如果进行年龄校正，则用于筛查舒张功能障碍。
