Sawin C T, Carlson H E, Geller A, Castelli W P, Bacharach P
Veterans Administration Medical Center, Boston, Massachusetts.
J Gerontol. 1989 Jul;44(4):M131-5. doi: 10.1093/geronj/44.4.m131.
We studied basal serum prolactin in older (greater than age 50) men (N = 501) and women (N = 384) using younger adults for comparison and excluding those taking medications. Serum prolactin rose slightly with increasing age in men; it fell slightly in women until age 80, when it rose slightly. Men and women were not different except for the higher value in women at age 20 to 29. Serum prolactin did not fall after the menopause, while estrogen treatment had no effect on older women and caused only a slight rise in older men. Thyroid deficiency had only a minimal effect and did not raise the serum prolactin above 25 ng/ml. The prevalence of clearly elevated values (greater than 20 ng/ml) was only 1.3% in women and 0.6% in men above age 50; there is little evidence for a significant prevalence of prolactin-secreting adenomata in older persons. In older persons, prolactin-secreting tumors are uncommon, and neither thyroid failure nor estrogen therapy are good explanations for a clearly elevated serum prolactin.
我们研究了年龄较大（50岁以上）男性（N = 501）和女性（N = 384）的基础血清催乳素水平，以年轻成年人作为对照，并排除正在服用药物的人群。男性血清催乳素水平随年龄增长略有上升；女性血清催乳素水平在80岁之前略有下降，之后略有上升。除20至29岁女性的血清催乳素水平较高外，男性和女性之间并无差异。绝经后血清催乳素水平并未下降，雌激素治疗对老年女性没有影响，而仅使老年男性的血清催乳素水平略有升高。甲状腺功能减退的影响极小，并未使血清催乳素水平升高至25 ng/ml以上。50岁以上女性血清催乳素水平明显升高（大于20 ng/ml）的患病率仅为1.3%，男性为0.6%；几乎没有证据表明老年人中存在大量分泌催乳素的腺瘤。在老年人中，分泌催乳素的肿瘤并不常见，甲状腺功能减退和雌激素治疗都不能很好地解释血清催乳素水平明显升高的原因。
