布德林A对人中性粒细胞和淋巴细胞的影响。
Effects of budlein A on human neutrophils and lymphocytes.
作者信息
Knob Carollinie Dias, Silva Milena, Gasparoto Thaís Helena, Oliveira Carine Ervolino, Amôr Nádia Ghinelli, Arakawa Nilton Syogo, Costa Fernando Batista, Campanelli Ana Paula
机构信息
- Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Bauru, SP, Brasil.
- Universidade Estadual de Londrina, Londrina, PR, Brasil.
出版信息
J Appl Oral Sci. 2016 May-Jun;24(3):271-7. doi: 10.1590/1678-775720150540.
OBJECTIVE
In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes.
MATERIAL AND METHODS
Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases.
RESULTS
Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death.
CONCLUSIONS
Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.
目的
在本研究中，我们评估了布德林A是否能调节中性粒细胞和淋巴细胞等先天性和适应性免疫细胞的激活。
材料与方法
我们的研究小组对多种植物物种进行了研究，分离、鉴定了多种化合物，并评估了它们的医学潜力。布德林A是从阿尔达马醉鱼草和粗壮阿尔达马（菊科）中分离出的一种倍半萜内酯，具有抗炎和抗伤害感受活性。在理解植物源物质如何调节先天性和适应性免疫细胞激活方面的进展，已促成了针对人类疾病的新疗法的开发。
结果
布德林A抑制髓过氧化物酶（MPO）活性、白细胞介素-6（IL-6）、CXC趋化因子配体8（CXCL8）、白细胞介素-10（IL-10）和白细胞介素-12的产生，并诱导中性粒细胞凋亡。相比之下，布德林A抑制淋巴细胞增殖以及白细胞介素-2（IL-2）、白细胞介素-10（IL-10）、转化生长因子-β（TGF-β）和干扰素-γ（IFN-γ）的产生，但不会导致细胞死亡。
结论
总体而言，我们的结果表明布德林A对免疫细胞具有明显的免疫调节作用。
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