Arthritis Res Ther. 2013 Oct 2;15(5):219. doi: 10.1186/ar4325.
Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles that neutrophils and aberrant neutrophil cell death play in the pathogenesis of various systemic autoimmune diseases, including systemic lupus erythematosus, small vessel vasculitis and rheumatoid arthritis.
中性粒细胞已成为先天和适应性免疫反应的重要调节因子。最近的证据表明，中性粒细胞在各种系统性自身免疫性疾病中表现出明显的表型和功能异常，并且可能在这些疾病中异常免疫反应和器官损伤的起始和持续中发挥核心作用。本文讨论了中性粒细胞和异常中性粒细胞死亡在各种系统性自身免疫性疾病发病机制中的可能作用，包括红斑狼疮、小血管血管炎和类风湿关节炎。
