Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2400 Copenhagen NV, Denmark. Department of Biomedical Sciences, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2400 Copenhagen NV, Denmark.
Sci Transl Med. 2016 Jul 6;8(346):346ra90. doi: 10.1126/scitranslmed.aad8335.
The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.
关节软骨的再生能力差是一个主要的临床挑战，这可能与软骨胶原基质的有限更新有关。然而，一生中的胶原更新率尚不清楚，并且关于骨关节炎（OA）是否会影响胶原更新率也存在争议。使用碳-14（¹⁴C）炸弹脉冲法，测量了 23 名出生于 1935 年至 1997 年之间的人的胫骨平台软骨中的终生胶原替换率（分别有 15 人和 8 人患有 OA 和健康软骨）。在软骨胶原中观察到的¹⁴C 水平表明，在骨骼成熟后，胶原基质几乎没有被替换，并且 OA 或组织损伤本身并不影响胶原更新率。关节表面的¹⁴C 含量的区域差异表明，关节表面中央的软骨胶原比关节表面周围的胶原形成早几年。人类关节软骨的胶原基质是一种基本的永久性结构，即使发生疾病，在成年人中也没有明显的更新。
