Phaosavasdi S, Snidvongs W, Thasanapradit P, Ungthavorn P, Bhongsvej S, Jongpiputvanich S, Vesjajiva S, Udomsantisuk P, Chitwarakorn A, Panikabutra K
J Med Assoc Thai. 1989 Feb;72(2):101-8.
The intramuscular injection of benzathine penicillin G 2.4 million units weekly for 3 consecutive weeks to syphilitic pregnant women was again confirmed to be clinically effective for prevention of their neonates from congenital syphilis and well accepted as treatment for syphilis in pregnancy. It was administered to 184 cases, or 93.5 per cent, of 197 syphilitic gravidas. It was found that pregnancy outcomes in terms of abortion, stillbirth, prematurity, full term delivery, neonatal birth weight, macroscopic examination of the placenta and general physical examination of the neonate were clinically useful as a parameter to evaluate the effectiveness of the therapy for the infant. Clinical symptoms and signs in the mother, serological tests for syphilis in the gravida and cord blood of the newborn, and placental weight were not useful in the evaluation of adequacy of treatment of our study group.
对梅毒孕妇连续3周每周肌内注射240万单位苄星青霉素G，再次证实其对预防新生儿先天性梅毒具有临床疗效，并且作为孕期梅毒的治疗方法被广泛接受。197例梅毒孕妇中有184例（93.5%）接受了该治疗。结果发现，流产、死产、早产、足月分娩、新生儿出生体重、胎盘宏观检查以及新生儿全身体格检查等妊娠结局，在临床上可作为评估该疗法对婴儿疗效的参数。母亲的临床症状和体征、孕妇及新生儿脐血梅毒血清学检测以及胎盘重量，对评估我们研究组的治疗是否充分并无帮助。
