Yuan Liqun, Hu Shu, Okray Zeynep, Ren Xi, De Geest Natalie, Claeys Annelies, Yan Jiekun, Bellefroid Eric, Hassan Bassem A, Quan Xiao-Jiang
VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium.
VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium Medical College, Henan University of Science and Technology, Luoyang, Henan Province 471003, China.
Development. 2016 Aug 1;143(15):2760-6. doi: 10.1242/dev.134155. Epub 2016 Jul 6.
The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homolog, Tap, of unknown function. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body, a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled.
神经生成素（Ngn）转录因子控制哺乳动物皮质中的早期神经发生和神经突生长。与其神经源性活性相反，它们在神经突生长中的功能却知之甚少。果蝇有一种单一的预测Ngn同源物Tap，其功能未知。在此我们表明，Tap在果蝇中不是神经源性蛋白，但对于蘑菇体神经元的轴突正常生长和导向是必需的，蘑菇体是一种与联想学习和记忆有关的神经纤维丛。遗传和表达分析表明，Tap通过精细调节Wnt信号衔接蛋白Dishevelled的水平来抑制轴突过度生长。
