Herbert Gleiter Institute of Nanoscience, Nanjing University of Science & Technology , 200 Xiaolingwei, Nanjing 210094, China.
Supermolecules Group, WPI Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
ACS Appl Mater Interfaces. 2016 Jul 27;8(29):18922-9. doi: 10.1021/acsami.6b02507. Epub 2016 Jul 18.
Silver has been recognized as a broad-spectrum antimicrobial agent and extensively used in biomedical applications. Through a sequential one-pot synthesis strategy, we have successfully incorporated silver into flake-shell nanoparticles. Due to the simultaneous growth of networked nanostructures of silica and in situ reduction of silver ions, homogeneously distributed silver into the shell of the nanocapsule was formed. The antibacterial test indicated that the silver-incorporated silica nanocapsule exhibits effective antibacterial activity, inhibiting the bacterial growth by 75%. In addition, with the encapsulation of other antibiotic agent into the structure, an enhanced antibacterial effect under dual-modality could also be achieved.
银已被公认为一种广谱抗菌剂，并广泛应用于生物医学领域。通过顺序一锅合成策略，我们成功地将银掺入了薄片壳纳米粒子中。由于同时生长的硅网络状纳米结构和银离子的原位还原，均匀分布的银被形成在纳米胶囊的壳中。抗菌试验表明，掺入银的硅纳米胶囊具有有效的抗菌活性，能抑制细菌生长 75%。此外，通过将其他抗生素封装到结构中，还可以实现双模式下的增强抗菌效果。
