Spherical and Spindle-Like Abamectin-Loaded Nanoparticles by Flash Nanoprecipitation for Southern Root-Knot Nematode Control: Preparation and Characterization.

Southern root-knot nematode () is a biotrophic parasite, causing enormous loss in global crop production annually. Abamectin (Abm) is a biological and high-efficiency pesticide against . In this study, a powerful method, flash nanoprecipitation (FNP), was adopted to successfully produce Abm-loaded nanoparticle suspensions with high drug loading capacity (>40%) and encapsulation efficiency (>95%), where amphiphilic block copolymers (BCPs) poly(lactic-co-glycolic acid)--poly(ethylene glycol) (PLGA--PEG), poly(d,l-lactide)--poly(ethylene glycol) (PLA--PEG), or poly(caprolactone)--poly(ethylene glycol) (PCL--PEG) were used as the stabilizer to prevent the nanoparticles from aggregation. The effect of the drug-to-stabilizer feed ratio on the particle stability were investigated. Moreover, the effect of the BCP composition on the morphology of Abm-loaded nanoparticles for controlling were discussed. Notably, spindle-like nanoparticles were obtained with PCL--PEG as the stabilizer and found significantly more efficient (98.4% mortality at 1 ppm particle concentration) than spherical nanoparticles using PLGA--PEG or PLA--PEG as the stabilizer. This work provides a more rapid and powerful method to prepare stable Abm-loaded nanoparticles with tunable morphologies and improved effectiveness for controlling .