Kennedy G L, Pruett J W
Haskell Laboratory for Toxicology, E.I. du Pont de Nemours and Company, Newark, DE 19714.
J Occup Med. 1989 Jan;31(1):47-50.
The determination of urinary N-monomethylacetamide (MMAC) in the end-of-shift urine sample was used to monitor exposure to dimethylacetamide (DMAC). Five workers were observed followed for 4 consecutive weeks. Airborne DMAC appeared to account for the greatest amount of urinary MMAC detected and, at the exposure concentrations encountered (0.5 to 2 ppm), a relationship of 10 ppm urinary MMAC for each 1 ppm DMAC inhaled was observed. Interindividual variation was small and no evidence of build-up in MMAC urinary levels was seen in these subjects. Mean airborne DMAC concentrations were somewhat higher by the end of the week, but the magnitude was such that the differences were not statistically significant. It is concluded that changes in DMAC exposures can be quantitatively reflected by urinary MMAC.
通过测定轮班结束时尿液样本中的尿 N-单甲基乙酰胺（MMAC）来监测二甲基乙酰胺（DMAC）的接触情况。观察了 5 名工人，连续跟踪 4 周。空气中的 DMAC 似乎是检测到的尿中 MMAC 的最大来源，在遇到的暴露浓度（0.5 至 2 ppm）下，观察到每吸入 1 ppm DMAC，尿中 MMAC 为 10 ppm 的关系。个体间差异很小，在这些受试者中未发现尿中 MMAC 水平升高的迹象。到周末时，空气中 DMAC 的平均浓度略高，但幅度不大，差异无统计学意义。结论是，DMAC 暴露的变化可通过尿中 MMAC 进行定量反映。
