Ismaiel M O, Greenman J, Morgan K, Glover M G, Rees A S, Scully C
Department of Oral Medicine, Surgery, and Pathology, Bristol University, United Kingdom.
J Periodontol. 1989 May;60(5):279-84. doi: 10.1902/jop.1989.60.5.279.
The use of sheep as a suitable animal model of destructive forms of human periodontal disease has been assessed from comparative radiological, histological, and serological investigations of sheep with and without periodontal disease. The results showed that, in sheep with periodontitis, bone resorption, collagen breakdown, degradation of blood capillary vessel walls, cellular infiltration of plasma cells, lymphocytes, and epithelial infiltration were significantly greater than in sheep without periodontitis, and the features are similar to those in rapidly destructive forms of periodontal disease in man. The levels of serum IgG antibody reactive against B. gingivalis antigens (measured by ELISA) were significantly higher in sheep with periodontitis than those without, similar to the association reported in some types of human periodontal diseases. These findings suggest that periodontitis in sheep could represent a suitable animal experimental model for certain types of rapidly destructive human periodontal diseases.
通过对患有和未患有牙周病的绵羊进行比较放射学、组织学和血清学研究，评估了将绵羊用作人类破坏性牙周病合适动物模型的可行性。结果表明，患有牙周炎的绵羊的骨吸收、胶原蛋白分解、毛细血管壁降解、浆细胞和淋巴细胞的细胞浸润以及上皮浸润明显高于未患牙周炎的绵羊，这些特征与人类快速破坏性牙周病的特征相似。通过酶联免疫吸附测定法（ELISA）测量，患有牙周炎的绵羊中针对牙龈卟啉单胞菌抗原的血清IgG抗体水平明显高于未患牙周炎的绵羊，这与某些类型人类牙周病中报道的关联相似。这些发现表明，绵羊牙周炎可能是某些类型人类快速破坏性牙周病的合适动物实验模型。
