Arnone Maria Ina, Andrikou Carmen, Annunziata Rossella
Stazione Zoologica Anton Dohrn, villa comunale, 80121 Napoli, Italy.
Stazione Zoologica Anton Dohrn, villa comunale, 80121 Napoli, Italy.
Curr Opin Genet Dev. 2016 Aug;39:129-137. doi: 10.1016/j.gde.2016.05.027. Epub 2016 Jul 4.
One of the main challenges in Evolutionary Developmental Biology is to understand to which extent developmental changes are driven by regulatory alterations in the genomic sequence. In the recent years, the focus of comparative developmental studies has moved towards a systems biology approach providing a better understanding of the evolution of gene interactions that form the so called Gene Regulatory Networks (GRN). Echinoderms provide a powerful system to reveal regulatory mechanisms and within the past decade, due to the latest technological innovations, a great number of studies have provided valuable information for comparative GRN analyses. In this review we describe recent advances in evolution of GRNs arising from echinoderm systems, focusing on the properties of conserved regulatory kernels, circuit co-option events and GRN topological rearrangements.
进化发育生物学的主要挑战之一是了解发育变化在多大程度上是由基因组序列中的调控改变所驱动的。近年来，比较发育研究的重点已转向系统生物学方法，以便更好地理解形成所谓基因调控网络（GRN）的基因相互作用的进化。棘皮动物提供了一个强大的系统来揭示调控机制，在过去十年中，由于最新的技术创新，大量研究为比较基因调控网络分析提供了有价值的信息。在这篇综述中，我们描述了棘皮动物系统中基因调控网络进化的最新进展，重点关注保守调控核心、回路共选事件和基因调控网络拓扑重排的特性。
