Stienen Martin N, Joswig Holger, Smoll Nicolas R, Corniola Marco V, Schaller Karl, Hildebrandt Gerhard, Gautschi Oliver P
Department of Neurosurgery and Faculty of Medicine, University Hospital Geneva, Geneva, Switzerland.
Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
World Neurosurg. 2016 Sep;93:458-465.e1. doi: 10.1016/j.wneu.2016.06.120. Epub 2016 Jul 5.
This study assessed whether predominant back pain (pBP) represents a negative outcome predictor in patients undergoing microscopic spine surgery without fusion for a lumbar disc herniation (LDH) or spinal stenosis (LSS).
Retrospective analysis of prospectively collected data on consecutive patients with LDH or LSS at 2 centers. Patients with visual analog scale (VAS) back pain ≥VAS leg pain were assigned to the pBP group, and compared with patients with predominant VAS leg pain (pLP). Outcome measures included the Roland-Morris Disability Index (RMDI), Oswestry Disability Index (ODI), health-related quality of life measures, Short-Form (SF)-12 Physical Component Summary (PCS), and EuroQol (EQ-5D) index at 3 days, 6 weeks (W6), 6 months, and 1 year postoperatively.
A total of 325 patients (154 [47.4%] with pBP and 171 [52.6%] with pLP) were included. Patients with pBP were about 6 years older and more often had LSS. There was no significant difference between the group means of the RMDI, ODI, SF-12 PCS, or EQ-5D at any postoperative time point. The most improvement was observed until the W6 follow-up with little or no improvement thereafter up to 1 year postoperatively. Patients with pBP were as likely as patients with pLP to be W6 responders on the RMDI (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.38-2.16; P = 0.831), ODI (OR, 1.00; 95% CI 0.52-1.92; P = 0.996), SF-12 PCS (OR, 1.09; 95% CI 0.58-2.04; P = 0.791), and EQ-5D (OR, 0.62; 95% CI 0.32-1.21; P = 0.164). Disease-specific subgroup analyses confirmed the results.
The present data suggest that patients with pBP have comparable functional and health-related quality of life outcomes after surgery for LDH or LSS with those of patients with pLP.
本研究评估了在接受腰椎间盘突出症(LDH)或腰椎管狭窄症(LSS)显微脊柱手术且未行融合术的患者中,以背痛为主(pBP)是否代表负面预后预测因素。
对两个中心连续的LDH或LSS患者前瞻性收集的数据进行回顾性分析。视觉模拟量表(VAS)背痛评分≥VAS腿痛评分的患者被分配到pBP组,并与以VAS腿痛为主(pLP)的患者进行比较。结局指标包括术后3天、6周(W6)、6个月和1年时的罗兰-莫里斯残疾指数(RMDI)、奥斯威斯残疾指数(ODI)、健康相关生活质量指标、简短形式(SF)-12身体成分总结(PCS)和欧洲五维度健康量表(EQ-5D)指数。
共纳入325例患者(154例[47.4%]为pBP,171例[52.6%]为pLP)。pBP患者年龄约大6岁,且更常患有LSS。在任何术后时间点,RMDI、ODI、SF-12 PCS或EQ-5D的组均值之间均无显著差异。术后直至W6随访时改善最为明显,此后直至术后1年几乎没有改善。pBP患者在RMDI(优势比[OR],0.91;95%置信区间[CI],0.38 - 2.16;P = 0.831)、ODI(OR,1.00;95% CI 0.52 - 1.92;P = 0.996)、SF-12 PCS(OR,1.09;95% CI 0.58 - 2.04;P = 0.791)和EQ-5D(OR,0.62;95% CI 0.32 - 1.21;P = 0.164)方面成为W6应答者的可能性与pLP患者相同。疾病特异性亚组分析证实了该结果。
目前的数据表明,对于LDH或LSS手术患者,pBP患者与pLP患者术后的功能和健康相关生活质量结局相当。