腰椎手术后1年和2年随访时患者报告的结局及其相关因素:一项手术登记研究

Patient-reported outcomes and their associated factors at 1- and 2-year follow-up after lumbar spine surgery: a surgery registry study.

作者信息

Cheng Ling Jie, Bansback Nick, Liu Gabriel Ka Po, Wang Wenru, Wu Vivien Xi, Luo Nan, Hey Hwee Weng Dennis

机构信息

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

出版信息

Qual Life Res. 2025 Sep 3. doi: 10.1007/s11136-025-04049-z.

Abstract

PURPOSE

Degenerative lumbar conditions are a leading cause of disability worldwide, often requiring surgery when conservative treatments fail. Data on surgical outcomes from patients' perspectives and influencing factors remain limited. This study aimed to assess 1-year and 2-year Patient-Reported Outcomes (PROs) following lumbar spine surgery and identify factors associated with these outcomes.

METHODS

This surgery registry study included 1,195 adult patients who underwent lumbar spine surgery between 2017 and 2022 at a tertiary hospital in Singapore. Patients completed the EQ-5D-3L and Oswestry Disability Index before surgery, as well as one year (n = 741) and two years (n = 440) after surgery. Multivariable logistic regression identified factors influencing PRO improvements at the dimension level.

RESULTS

The mean age of the patients was 58.1 years (SD 16.1). From baseline to 1-year, patients experienced the largest improvements in pain/discomfort (δ = 0.55-0.56) and social functioning (δ = 0.48-0.53), while improvements in activities of daily living and functional tasks were smaller, with negligible change in lifting (δ = 0.04); these effects largely persisted at the 2-year follow-up. Patients with poorer baseline PROs consistently improved across all PROs at the 1-year follow-up. Higher education and conditions affecting only the L4/5 spinal level were associated with better outcomes in activities of daily living, pain/discomfort, and social functioning. Higher education and a prolapsed disc diagnosis were associated with functional task improvements. At year two, poorer baseline PROs remained influential, while the absence of comorbidities emerged as a significant factor.

CONCLUSIONS

Substantial improvements in pain/discomfort and social functioning domains occurred within the first year and persisted into year two, while physically demanding tasks such as lifting remained difficult to restore. Patients with poorer baseline PROs and higher education derived the greatest benefit, emphasising tailored pre-operative interventions to optimise outcomes.

摘要

目的

退行性腰椎疾病是全球致残的主要原因,保守治疗失败时通常需要手术治疗。从患者角度来看的手术结果及影响因素的数据仍然有限。本研究旨在评估腰椎手术后1年和2年的患者报告结局(PROs),并确定与这些结局相关的因素。

方法

这项手术登记研究纳入了2017年至2022年在新加坡一家三级医院接受腰椎手术的1195名成年患者。患者在手术前、手术后1年(n = 741)和2年(n = 440)完成了EQ-5D-3L和奥斯威斯利残疾指数评估。多变量逻辑回归分析确定了在维度层面影响PRO改善的因素。

结果

患者的平均年龄为58.1岁(标准差16.1)。从基线到1年,患者在疼痛/不适(δ = 0.55 - 0.56)和社会功能(δ = 0.48 - 0.53)方面改善最大,而日常生活活动和功能任务的改善较小,提举能力的变化可忽略不计(δ = 0.04);这些效果在2年随访时基本持续存在。基线PROs较差的患者在1年随访时所有PROs均持续改善。高等教育以及仅影响L4/5脊髓节段的疾病与日常生活活动、疼痛/不适和社会功能方面的更好结局相关。高等教育和椎间盘突出诊断与功能任务改善相关。在第两年,较差的基线PROs仍然有影响,而无合并症成为一个重要因素。

结论

疼痛/不适和社会功能领域在第一年有显著改善,并持续到第二年,而诸如提举等体力要求较高的任务仍然难以恢复。基线PROs较差和接受高等教育的患者获益最大,强调进行有针对性的术前干预以优化结局。

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