Shimoyama H, Suwata J, Saitoh H, Oguchi K, Kobayashi S, Kawada Y
Nihon Jinzo Gakkai Shi. 1989 Feb;31(2):165-70.
An increase in the long-term survival ratio of patients with chronic renal failure has led to an increase in constant hypotensive accidents and cases of hypotension attacks during hemodialysis in spite of no prior abnormal physical findings, leading to difficulty in maintaining further dialysis. Many investigators have examined the plasma noradrenalin (NA) levels in dialysis patients, but the relationship between blood pressure and the plasma catecholamine concentration remains unknown. In our time-course plasma catecholamine level measurements, no significant difference was observed between the pre- and post-hemodialysis period, but a comparison of the plasma catecholamine levels for respective time periods revealed that a decrease in plasma NA levels corresponded to a decrease in blood pressure 3 to 4 hours after the beginning of hemodialysis. Administration of amezinium, which was thought to increase the plasma NA level, succeeded in maintaining and facilitated maintenance of a favorable blood pressure. The plasma NA concentration was considered to be related to a reduction of blood pressure during hemodialysis.
慢性肾衰竭患者长期生存率的提高，导致尽管之前没有异常体征，但在血液透析期间持续性低血压事故和低血压发作病例有所增加，从而难以维持进一步的透析。许多研究人员检测了透析患者的血浆去甲肾上腺素（NA）水平，但血压与血浆儿茶酚胺浓度之间的关系仍不清楚。在我们对血浆儿茶酚胺水平进行的时间进程测量中，血液透析前后未观察到显著差异，但对各个时间段的血浆儿茶酚胺水平进行比较发现，血浆NA水平的下降与血液透析开始3至4小时后的血压下降相对应。给予甲磺酸阿美铵，其被认为可提高血浆NA水平，成功维持并促进了良好血压的维持。血浆NA浓度被认为与血液透析期间血压降低有关。
