Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Department of Experimental Immunology, University of Amsterdam (UvA), Academic Medical Center (AMC), Amsterdam, The Netherlands.
Semin Immunopathol. 2016 Nov;38(6):727-738. doi: 10.1007/s00281-016-0578-9. Epub 2016 Jul 8.
Adaptation of the maternal immune system to establish maternal/fetal equilibrium is required for a successful pregnancy. Viral infections, including HIV-1 infection, can alter this maternal/fetal equilibrium, with significant consequences for pregnancy outcome, including miscarriages, impaired fetal growth, and premature delivery. Furthermore, maternal HIV-1 infection has been shown to have a long-term impact on the developing fetal immune system also when the infant is not infected with the virus. In this review, we discuss the consequences of maternal HIV-1 infection and antiretroviral therapy on pregnancy outcome and the health of the uninfected HIV-1-exposed infant.
母体免疫系统需要适应以建立母婴平衡，这是成功妊娠所必需的。病毒感染，包括 HIV-1 感染，可改变这种母婴平衡，对妊娠结局产生重大影响，包括流产、胎儿生长受损和早产。此外，即使婴儿未感染病毒，母体 HIV-1 感染也会对发育中的胎儿免疫系统产生长期影响。在这篇综述中，我们讨论了母体 HIV-1 感染和抗逆转录病毒治疗对妊娠结局和未感染 HIV-1 的暴露婴儿健康的影响。
