Rychter Marek, Gaucher Caroline, Boudier Ariane, Leroy Pierre, Lulek Janina
Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Université de Lorraine, CITHEFOR EA3452 "Drug Targets, Formulation and Preclinical Assessment", Faculté de Pharmacie, 5, rue A. Lebrun, F-54000 Nancy, France.
Int J Biochem Cell Biol. 2016 Sep;78:156-161. doi: 10.1016/j.biocel.2016.07.003. Epub 2016 Jul 6.
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) activates signaling pathways responsible for smooth muscle cell relaxation, leading to vasodilation and thus plays an important role in controlling vascular homeostasis, thrombosis and inflammation. Recent studies indicate that S-nitrosothiols produced in vivo as well as synthetic ones might be important reservoirs of NO. Based on a broad range of NO functions within the living organisms, this review highlights the impact of S-nitrosothiols on cardiovascular cell cycle. The cell membrane transport and the decomposition patterns responsible of S-nitrosothiols actions are presented. The effects of NO delivery through S-nitrosothiols have a significant potential in cardiovascular diseases with various underlying causes. The challenges related to their application in the pharmacotherapy of patients with various cardiovascular diseases are also discussed.
内皮型一氧化氮合酶（eNOS）产生的一氧化氮（NO）激活负责平滑肌细胞舒张的信号通路，导致血管舒张，因此在控制血管稳态、血栓形成和炎症中发挥重要作用。最近的研究表明，体内产生的以及合成的S-亚硝基硫醇可能是NO的重要储存库。基于NO在生物体中的广泛功能，本综述重点介绍了S-亚硝基硫醇对心血管细胞周期的影响。介绍了负责S-亚硝基硫醇作用的细胞膜转运和分解模式。通过S-亚硝基硫醇递送NO在各种潜在病因的心血管疾病中具有显著潜力。还讨论了将其应用于各种心血管疾病患者药物治疗中所面临的挑战。
