白色脂肪组织褐变：一把双刃剑。
White Adipose Tissue Browning: A Double-edged Sword.
作者信息
Abdullahi Abdikarim, Jeschke Marc G
机构信息
Institute of Medical Science, University of Toronto, Canada; Sunnybrook Research Institute, Totonto, Canada.
Institute of Medical Science, University of Toronto, Canada; Sunnybrook Research Institute, Totonto, Canada; Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada; Department of Surgery, Division of Plastic Surgery, Department of Immunology, University of Toronto, Canada.
出版信息
Trends Endocrinol Metab. 2016 Aug;27(8):542-552. doi: 10.1016/j.tem.2016.06.006. Epub 2016 Jul 5.
Abstract
The study of white adipose tissue (WAT) 'browning' has become a 'hot topic' in various acute and chronic metabolic conditions, based on the idea that WAT browning might be able to facilitate weight loss and improve metabolic health. However, this view cannot be translated into all areas of medicine. Recent studies identified effects of browning associated with adverse outcomes, and as more studies are being conducted, a very different picture has emerged about WAT browning and its detrimental effect in acute and chronic hypermetabolic conditions. Therefore, the notion that browning is supposedly beneficial may be inadequate. In this review we analyze how and why browning in chronic hypermetabolic associated diseases can be detrimental and lead to adverse outcomes.
摘要
基于白色脂肪组织（WAT）“褐变”可能有助于减肥和改善代谢健康的观点，WAT褐变的研究已成为各种急慢性代谢状况下的一个“热门话题”。然而，这种观点并不能推广到医学的所有领域。最近的研究发现了褐变与不良后果相关的影响，随着更多研究的开展，关于WAT褐变及其在急慢性高代谢状况下的有害作用出现了截然不同的情况。因此，认为褐变理应有益的观念可能并不充分。在这篇综述中，我们分析了慢性高代谢相关疾病中的褐变如何以及为何会产生有害影响并导致不良后果。
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