截瘫型吉兰-巴雷综合征：仅累及下肢的非脱髓鞘性可逆性传导障碍。
Paraparetic Guillain-Barré syndrome: Nondemyelinating reversible conduction failure restricted to the lower limbs.
作者信息
Kimachi Takeshi, Yuki Nobuhiro, Kokubun Norito, Yamaguchi Shuhei, Wakerley Benjamin R
机构信息
Department of Neurology, University of Shimane, Shimane, Japan.
Department of Neurology, Mishima Hospital, Niigata, Japan.
出版信息
Muscle Nerve. 2017 Feb;55(2):281-285. doi: 10.1002/mus.25242. Epub 2016 Nov 28.
INTRODUCTION
Paraparetic Guillain-Barré syndrome (GBS) is a rare subtype of GBS characterized by leg weakness and areflexia in the absence of neurological involvement of the arms, cranial nerves, or respiratory muscles. Onset is characterized by lower back, buttock, or leg pain, followed by development of symmetric flaccid limb weakness in the absence of sensory disturbance.
METHODS
We describe an elderly woman who developed postinfectious symmetric flaccid leg weakness in the absence of sensory disturbance. Serial nerve conduction studies were carried out over 5 months.
RESULTS
Antecedent infection, a monophasic disease course, and the presence of cerebrospinal fluid albuminocytological dissociation suggested a diagnosis of paraparetic GBS. Serial nerve conduction studies demonstrated nondemyelinating reversible conduction failure, which was restricted to the legs. Axonal neuropathy was supported by the presence of anti-GM1 IgG antibodies.
CONCLUSIONS
These findings suggest that patients with paraparetic GBS have axonal neuropathy, which is restricted to the lower limbs. Muscle Nerve 55: 281-285, 2017.
引言
双侧下肢轻瘫型吉兰 - 巴雷综合征（GBS）是GBS的一种罕见亚型，其特征为腿部无力和腱反射消失，而手臂、颅神经或呼吸肌无神经受累。起病时表现为下背部、臀部或腿部疼痛，随后在无感觉障碍的情况下出现对称性弛缓性肢体无力。
方法
我们描述了一位老年女性，她在无感觉障碍的情况下出现感染后对称性弛缓性腿部无力。在5个月内进行了系列神经传导研究。
结果
前驱感染、单相病程以及脑脊液蛋白细胞分离提示双侧下肢轻瘫型GBS的诊断。系列神经传导研究显示非脱髓鞘性可逆性传导阻滞，且仅限于腿部。抗GM1 IgG抗体的存在支持轴索性神经病的诊断。
结论
这些发现表明双侧下肢轻瘫型GBS患者存在仅限于下肢的轴索性神经病。《肌肉与神经》55: 281 - 285, 2017年。
Zotero 插件