Quitadamo Paolo, Thapar Nikhil, Staiano Annamaria, Borrelli Osvaldo
Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, UCL Institute of Child Health and Great Ormond Street Hospital, London, UK.
Eur J Paediatr Neurol. 2016 Nov;20(6):810-815. doi: 10.1016/j.ejpn.2016.05.019. Epub 2016 Jun 11.
The current increasing survival of children with severe central nervous system damage has created a major challenge for medical care. Gastrointestinal and nutritional problems in neurologically impaired children have been recently recognized as an integral part of their disease, often leading to growth failure and worsened quality of life for both children and caregivers. Nutritional support is essential for the optimal care of these children. Undernourished handicapped children might not respond properly to intercurrent diseases and suffer unnecessarily. On the other hand, restoring a normal nutritional status results in a better quality of life in many. The easiest and least invasive method to increase energy intake is to improve oral intake. However, oral intake can be maintained as long as there is no risk of aspiration, the child is growing well and the time required to feed the child remains within acceptable limits. When oral intake is unsafe, insufficient or too time consuming, enteral nutrition should be initiated. Damage to the developing central nervous system may result in significant dysfunction in the gastrointestinal tract and is reflected in impairment in oral-motor function, rumination, gastro-oesophageal reflux (GER), with or without aspiration, delayed gastric emptying and constipation. These problems can all potentially contribute to feeding difficulty in disabled children, carrying further challenging long-term management issues.
目前,患有严重中枢神经系统损伤的儿童存活率不断提高,这给医疗护理带来了重大挑战。神经功能受损儿童的胃肠道和营养问题最近已被视为其疾病的一个组成部分,常常导致生长发育迟缓,儿童及其照顾者的生活质量下降。营养支持对于这些儿童的最佳护理至关重要。营养不良的残疾儿童可能无法对并发疾病做出适当反应,从而遭受不必要的痛苦。另一方面,恢复正常营养状况可使许多人的生活质量得到改善。增加能量摄入最简单、侵入性最小的方法是改善经口摄入。然而,只要没有误吸风险、儿童生长良好且喂养儿童所需时间在可接受范围内,就可以维持经口摄入。当经口摄入不安全、不足或耗时过长时,应开始肠内营养。发育中的中枢神经系统受损可能导致胃肠道严重功能障碍,表现为口腔运动功能受损、反刍、胃食管反流(GER)(无论有无误吸)、胃排空延迟和便秘。这些问题都可能导致残疾儿童喂养困难,带来更具挑战性的长期管理问题。