Lyu Jinli, Zhang Xiaowei, Xiong Shenghua, Wu Hui, Han Jing, Xie Yongjie, Qiu Feifeng, Yang Zhenyu, Huang Congfu
Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Department of Pediatrics, Longgang District Maternity and Child Healthcare Hospital, Shenzhen, China.
Front Pediatr. 2024 Aug 22;12:1440190. doi: 10.3389/fped.2024.1440190. eCollection 2024.
Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota.
Fecal samples from 32 children were collected, among whom those cared for by family ( = 21) were selected as the observation group, and those cared for by children's welfare institutions ( = 11) were selected as the control group (registration number of LGFYYXLL-024). The gut microbiota profiles were analyzed.
There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria and ( < 0.05), and a significant decrease in the abundance of opportunistic pathogens , cluster IV, , and ( < 0.05). Additionally, lipid metabolism, carbohydrate metabolism, transcription, cellular processes and signaling, and membrane transport were significantly upregulated in the observation group. Lipid metabolism was positively correlated with and , indicating a positive impact of the family-centered care mode on bacterial metabolism processes.
This study highlights that the family-centered care mode had a positive impact on the composition and function of the gut microbiota. The study provides valuable insights into the relationship between care mode and gut microbiota, which can inspire the development of interventions for cerebral palsy.
专业护理对于脑瘫儿童的康复至关重要。本研究调查了不同护理模式如何影响肠道微生物群。
收集了32名儿童的粪便样本，其中选择由家庭照顾的儿童（n = 21）作为观察组，由儿童福利院照顾的儿童（n = 11）作为对照组（伦理审查批准号：LGFYYXLL - 024）。对肠道微生物群谱进行了分析。
肠道微生物群的α多样性和门水平的丰度没有显著差异。然而，在属水平上，观察组中产生丁酸盐的细菌[X]和[X]的丰度显著增加（P < 0.05），机会性病原体[X]、IV群、[X]和[X]的丰度显著降低（P < 0.05）。此外，观察组中脂质代谢、碳水化合物代谢、转录、细胞过程和信号传导以及膜转运显著上调。脂质代谢与[X]和[X]呈正相关，表明以家庭为中心的护理模式对细菌代谢过程有积极影响。
本研究强调以家庭为中心的护理模式对肠道微生物群的组成和功能有积极影响。该研究为护理模式与肠道微生物群之间的关系提供了有价值的见解，可启发脑瘫干预措施的开发。
