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通过对多个组织RNA测序数据进行荟萃分析来鉴定肺特异性基因。

Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data.

作者信息

Xiong Min, Heruth Daniel P, Zhang Li Qin, Ye Shui Qing

机构信息

Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA; Department of Biomedical and Health Informatics University of Missouri Kansas City School of Medicine MO USA.

Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA.

出版信息

FEBS Open Bio. 2016 Jun 16;6(7):774-81. doi: 10.1002/2211-5463.12089. eCollection 2016 Jul.

DOI:10.1002/2211-5463.12089
PMID:27398317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4932457/
Abstract

Lung-specific genes play critically important roles in lung development, lung physiology, and pathogenesis of lung-associated diseases. We performed a meta-analysis of multiple tissue RNA-seq data to identify lung-specific genes in order to better investigate their lung-specific functions and pathological roles. We identified 83 lung-specific genes consisting of 62 protein-coding genes, five pseudogenes and 16 noncoding RNA genes. About 49.4% of lung-specific genes were implicated in the pathogenesis of lung diseases and 21.7% were involved with lung development. The identification of genes with enriched expression in the lung will facilitate the elucidation of lung-specific functions and their roles in disease pathogenesis.

摘要

肺特异性基因在肺发育、肺生理学以及肺部相关疾病的发病机制中起着至关重要的作用。我们对多个组织的RNA测序数据进行了荟萃分析，以鉴定肺特异性基因，以便更好地研究它们的肺特异性功能和病理作用。我们鉴定出了83个肺特异性基因，其中包括62个蛋白质编码基因、5个假基因和16个非编码RNA基因。约49.4%的肺特异性基因与肺部疾病的发病机制有关，21.7%与肺发育有关。鉴定出在肺中表达丰富的基因将有助于阐明肺特异性功能及其在疾病发病机制中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/aa6ecd899a1a/FEB4-6-774-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/5405ff9f2e9c/FEB4-6-774-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/778a7bb68881/FEB4-6-774-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/830f618e7877/FEB4-6-774-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/aa6ecd899a1a/FEB4-6-774-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/5405ff9f2e9c/FEB4-6-774-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/778a7bb68881/FEB4-6-774-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/830f618e7877/FEB4-6-774-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c1/4932457/aa6ecd899a1a/FEB4-6-774-g005.jpg

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本文引用的文献

1
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2
Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants.表达图谱更新——一个关于人类、动物和植物基因与蛋白质表达的综合数据库。
Nucleic Acids Res. 2016 Jan 4;44(D1):D746-52. doi: 10.1093/nar/gkv1045. Epub 2015 Oct 19.
3
Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study.
血液中循环游离RNA作为检测结核病的宿主反应生物标志物
medRxiv. 2023 Jan 11:2023.01.11.23284433. doi: 10.1101/2023.01.11.23284433.
4
Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome.先天性心脏病中新生突变的系统分析确定了左心发育不全综合征中的蛋白质网络。
Cell Syst. 2022 Nov 16;13(11):895-910.e4. doi: 10.1016/j.cels.2022.09.001. Epub 2022 Sep 26.
5
Gene expression profiling of postnatal lung development in the marsupial gray short-tailed opossum (Monodelphis domestica) highlights conserved developmental pathways and specific characteristics during lung organogenesis.对有袋动物灰短尾负鼠（Monodelphis domestica）出生后肺发育的基因表达谱进行分析，突出了肺器官发生过程中保守的发育途径和特定特征。
BMC Genomics. 2018 Oct 5;19(1):732. doi: 10.1186/s12864-018-5102-2.
6
Novel Genetic Variants Associated with Child Refractory Esophageal Stricture with Food Allergy by Exome Sequencing.通过外显子组测序鉴定与患有食物过敏的儿童难治性食管狭窄相关的新型基因变异
Nutrients. 2017 Apr 15;9(4):390. doi: 10.3390/nu9040390.
通过基于表达的全基因组关联研究鉴定急性呼吸窘迫综合征的新生物标志物。
BMC Pulm Med. 2015 Aug 19;15:95. doi: 10.1186/s12890-015-0088-x.
4
Paradigm shifts in genomics through the FANTOM projects.通过FANTOM项目实现的基因组学范式转变。
Mamm Genome. 2015 Oct;26(9-10):391-402. doi: 10.1007/s00335-015-9593-8. Epub 2015 Aug 8.
5
Understanding multicellular function and disease with human tissue-specific networks.利用人类组织特异性网络理解多细胞功能与疾病。
Nat Genet. 2015 Jun;47(6):569-76. doi: 10.1038/ng.3259. Epub 2015 Apr 27.
6
Proteomics. Tissue-based map of the human proteome.蛋白质组学。人类蛋白质组组织图谱。
Science. 2015 Jan 23;347(6220):1260419. doi: 10.1126/science.1260419.
7
Ensembl 2015.Ensembl 2015.
Nucleic Acids Res. 2015 Jan;43(Database issue):D662-9. doi: 10.1093/nar/gku1010. Epub 2014 Oct 28.
8
The effectiveness of the serum surfactant protein D (Sp-D) level to indicate lung injury in pulmonary embolism.血清表面活性蛋白D（Sp-D）水平用于指示肺栓塞中肺损伤的有效性。
Clin Lab. 2014;60(9):1457-64. doi: 10.7754/clin.lab.2013.131009.
9
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.通过整合转录组学和基于抗体的分析所定义的肺特异性蛋白质组。
FASEB J. 2014 Dec;28(12):5184-96. doi: 10.1096/fj.14-254862. Epub 2014 Aug 28.
10
Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.长链非编码RNA与转录因子在空间上相关，并调节肺的发育。
Genes Dev. 2014 Jun 15;28(12):1363-79. doi: 10.1101/gad.238782.114.