Umarao Preeti, Bose Samrat, Bhattacharyya Supti, Kumar Anil, Jain Suman
J Nanosci Nanotechnol. 2016 Jan;16(1):261-9. doi: 10.1166/jnn.2016.11103.
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the dopaminergic neurons of the substantia nigra leading to various motor and non-motor deficits. We explored the neuroprotective potential of superparamagnetic iron oxide nanoparticles (IONPs) along with exposure to EMF in 6-OHDA rat model of PD. IONPs were implanted at the site of lesion and 24 h thereafter the rats were exposed to magnetic fields 2 h/day for one week. Bilateral lesions of the striatum were made with 6-OHDA. The rats in all the intervention groups improved progressively over the days and by post-surgery day 4 they were active and bright. We observed a significant beneficial effect of the IONPs implantation and MF exposure on feeding behavior, gait and postural stability. There was a significant enhancement of mitochondrial function and attenuation of lesion volume in all the intervention groups as compared to PD. The results demonstrate neuroprotective effect of iron oxide nanoparticle implantation and magnetic field exposure in an in vivo 6-OHDA rat model of PD.
帕金森病（PD）是一种进行性神经退行性疾病，主要影响黑质中的多巴胺能神经元，导致各种运动和非运动功能缺陷。我们在6-羟基多巴胺（6-OHDA）诱导的帕金森病大鼠模型中，研究了超顺磁性氧化铁纳米颗粒（IONPs）以及暴露于电磁场（EMF）的神经保护潜力。IONPs被植入损伤部位，24小时后，大鼠每天暴露于磁场2小时，持续一周。用6-OHDA造成双侧纹状体损伤。所有干预组的大鼠在术后数天逐渐好转，到术后第4天，它们变得活跃且精神饱满。我们观察到IONPs植入和磁场暴露对进食行为、步态和姿势稳定性有显著的有益影响。与帕金森病组相比，所有干预组的线粒体功能均有显著增强，损伤体积减小。结果表明，在体内6-OHDA诱导的帕金森病大鼠模型中，氧化铁纳米颗粒植入和磁场暴露具有神经保护作用。
