Li Wei, Zhang Guoxiang, Sheng Wenbo, Liu Zhiyong, Jia Xin
J Nanosci Nanotechnol. 2016 Jan;16(1):576-80. doi: 10.1166/jnn.2016.10676.
Recent years, many methods have been developed to widen the practical application of single-walled carbon nanotubes (SWCNTs). Among them, PEGylation is a general strategy to endow functionality, biocompatibility as well as its good solubility. In this paper, poly(ethylene glycol) (PEG) is successfully grafted onto SWCNTs through living anionic ring-opening polymerization of ethylene oxide (EO). By controlling the amount of monomer and initiator, a series of PEGylated SWCNTs with different PEG molecular weight and density are prepared. Then, the as-prepared SWCNTs have been verified by thermogravimetric analyses (TGA), Raman spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS). Finally, the protein resistance property of the PEGylated SWCNTs is investigated. It is found that these PEGylated SWCNTs have a good protein resistance property and the higher the content of PEG grafted on the SWCNTs, the less adsorption amount of BSA and the larger capacity to resist protein absorption. This work provides a novel method to prepare PEGylated SWCNTs.
近年来，已经开发了许多方法来扩大单壁碳纳米管（SWCNTs）的实际应用。其中，聚乙二醇化是赋予功能、生物相容性以及良好溶解性的通用策略。在本文中，通过环氧乙烷（EO）的活性阴离子开环聚合，聚乙二醇（PEG）成功接枝到SWCNTs上。通过控制单体和引发剂的量，制备了一系列具有不同PEG分子量和密度的聚乙二醇化SWCNTs。然后，通过热重分析（TGA）、拉曼光谱、傅里叶变换红外（FT-IR）光谱、X射线光电子能谱（XPS）对所制备的SWCNTs进行了验证。最后，研究了聚乙二醇化SWCNTs的抗蛋白质性能。发现这些聚乙二醇化SWCNTs具有良好的抗蛋白质性能，并且接枝在SWCNTs上的PEG含量越高，牛血清白蛋白的吸附量越少，抗蛋白质吸附能力越大。这项工作提供了一种制备聚乙二醇化SWCNTs的新方法。
