School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi, 832003, China.
Macromol Biosci. 2013 Sep;13(9):1259-66. doi: 10.1002/mabi.201300157. Epub 2013 Jul 31.
A reliable and easy method is developed to confer protein resistance and drug controlled release dual functions to single-walled carbon nanotubes (SWNTs) by modification with a polydopamine (Pdop) layer and poly(oligo(ethylene glycol) methacrylate) (POEGMA) brushes. The study of protein resistance demonstrates that POEGMA-modified SWNTs exhibit higher protein resistance than pristine SWNTs, and the protein resistance ability is dependant on the length of the POEGMA molecule. Furthermore, the Pdop layer can serve as a pH-responsive switch for controlled loading and release of rhodamine 6G. The integration of protein resistance and pH-responsive controlled release make the double-layer modified SWNTs attractive for drug delivery in cancer therapy.
通过聚多巴胺（Pdop）层和聚（聚乙二醇甲基丙烯酸酯）（POEGMA）刷的修饰，开发了一种将蛋白质抗性和药物控制释放双重功能赋予单壁碳纳米管（SWNTs）的可靠且简单的方法。蛋白质抗性研究表明，POEGMA 修饰的 SWNTs 比原始 SWNTs 具有更高的蛋白质抗性，并且蛋白质抗性能力取决于 POEGMA 分子的长度。此外，Pdop 层可用作 pH 响应开关，用于控制罗丹明 6G 的加载和释放。蛋白质抗性和 pH 响应控制释放的集成使双层修饰的 SWNTs 成为癌症治疗中药物输送的有吸引力的选择。
