Lewandowski Bogumił, Brodowski Robert, Pakla Paweł, Stopyra Wojciech, Gawron Iwona
Department of Maxillo-Facial Surgery, Fr. Chopin Clinical Voivodeship Hospital Chair of Emergency Medical Service, Faculty of Medicine, the University of Rzeszow Department of Radiotherapy, Subcarpathian Oncology Centre, Rzeszow, Poland.
Medicine (Baltimore). 2016 Jul;95(27):e4011. doi: 10.1097/MD.0000000000004011.
Leiomyosarcoma (LMS) is a malignancy which very rarely occurs in maxillofacial location, and the course of the disease is not very characteristic.In this case report, we present a 58-year-old female patient with a painless tumor of the left angle of the mandible causing slight asymmetry of the face. She also reported that she observed deterioration in fitting of the lower denture in the oral cavity for several months, which she had used successfully for 5 years.On the basis of clinical tests, histopatological examination, and imaging (CT, MRI, ultrasound, pantomography), the patient was diagnosed with primary malignant leiomyosarcoma (LMS) of the mandibular corpus and ramus on the left side. The patient received combined surgical and oncological treatment. The first stage was a surgery, and then adjuvant radiotherapy was applied on the site of the resected tumor-a total dose of 60 Gy in 35 fractions. The patient's postoperative course was uneventful. She also underwent adjuvant therapy well. In the period of 3-year follow-up, no signs of recurrence were observed.The findings may extend our knowledge and experiences in the treatment of leiomvosarcoma in the craniofacial area.
平滑肌肉瘤（LMS）是一种极为罕见于颌面部位的恶性肿瘤，其病程并无十分典型的特征。在本病例报告中，我们呈现了一位58岁女性患者，其左下颌角有无痛性肿瘤，导致面部轻度不对称。她还报告称，她注意到自己使用了5年的下义齿在口腔中的贴合度在几个月里变差了。基于临床检查、组织病理学检查以及影像学检查（CT、MRI、超声、全景片），该患者被诊断为左侧下颌体及下颌支原发性恶性平滑肌肉瘤（LMS）。患者接受了手术与肿瘤学联合治疗。第一阶段是手术，然后在切除肿瘤的部位进行辅助放疗——总剂量60Gy，分35次照射。患者术后恢复顺利。她辅助治疗也进行得很好。在3年的随访期内，未观察到复发迹象。这些发现可能会扩展我们在颅面部平滑肌肉瘤治疗方面的知识和经验。
