Howard G, Brockschmidt J K, Rose L A, Frye-Pierson J L, Crouse J R, Evans G W, Mitchell E S, Toole J F
Stroke Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Neurology. 1989 Jul;39(7):982-5. doi: 10.1212/wnl.39.7.982.
We compared survival following transient ischemic attack (TIA) in 2 prospective cohorts of TIA patients admitted to Wake Forest University Medical Center. The 1st consisted of 177 patients admitted between 1961 and 1973, and the 2nd of 185 patients admitted between 1980 and 1983. Patients in the 2nd cohort had significantly greater longevity than patients in the 1st cohort, both univariately and after adjustment for cerebrovascular risk factors. The adjusted 1-year survival estimate increased from 91% in the 1st cohort to 98% in the 2nd, and the adjusted 3-year survival estimate increased from 83% in the 1st to 94% in the 2nd. The underlying causes for this dramatic improvement in survival may include early identification and aggressive management of TIAs or coexisting diseases, improved management of subsequent completed strokes or myocardial infarctions, or unadjusted differences in these cohorts. The data imply that reports of TIA survival from different periods may not be comparable.
我们比较了维克森林大学医学中心收治的两个前瞻性短暂性脑缺血发作（TIA）患者队列的生存率。第一个队列由1961年至1973年间收治的177例患者组成，第二个队列由1980年至1983年间收治的185例患者组成。在单变量分析以及对脑血管危险因素进行调整之后，第二个队列患者的寿命均显著长于第一个队列患者。调整后的1年生存率估计值从第一个队列的91%升至第二个队列的98%，调整后的3年生存率估计值从第一个队列的83%升至第二个队列的94%。生存率出现这一显著改善的潜在原因可能包括对TIA或并存疾病的早期识别和积极管理、对随后发生的完全性卒中或心肌梗死的改善管理，或者这些队列中未调整的差异。数据表明，不同时期TIA生存率的报告可能不可比。
