Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia.
School of Pharmacy, Griffith University, Gold Coast 4222, Australia.
Antioxidants (Basel). 2016 Jul 5;5(3):22. doi: 10.3390/antiox5030022.
Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.
放射治疗是治疗恶性肿瘤的一种常用疗法，高达 60%的癌症患者在治疗方案中接受放射治疗。然而，放射治疗会引起一系列不良反应，这些反应可能很严重，并对患者造成永久性损害。为了尽量减少这些影响，已经确定了少量化合物，并在临床上用于预防和治疗与放射相关的毒性。此外，还有许多新兴的治疗方法正在开发中，用作预防放射诱导毒性的药物。本综述的目的是评估和总结现有的已知放射保护剂和有希望成为未来放射保护剂的药物的证据。
