Hall Susan, Desbrow Ben, Anoopkumar-Dukie Shailendra, Davey Andrew K, Arora Devinder, McDermott Catherine, Schubert Matthew M, Perkins Anthony V, Kiefel Milton J, Grant Gary D
Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Pharmacy, Griffith University, Queensland, Australia.
Menzies Health Institute Queensland, Griffith University, Queensland, Australia; School of Allied Health Sciences, Griffith University, Queensland, Australia.
Food Res Int. 2015 Oct;76(Pt 3):626-636. doi: 10.1016/j.foodres.2015.07.027. Epub 2015 Aug 4.
Coffee is a widely consumed beverage containing numerous biologically active constituents predominantly belonging to the polyphenol and alkaloid classes. It has been established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and retrospective cohort studies have assessed the effects of coffee consumption on the relative risk of developing major depressive disorder in humans. These studies have identified an inverse relationship between the consumption of caffeinated coffee and the risk of developing depression. Caffeine, chlorogenic acid, ferulic acid and caffeic acid, all important constituents of coffee, have been shown to possess biological activities that highlight a possible mechanistic link to the pathology of depression. This review aims to assess the evidence from the biological evaluation of these constituents of coffee on markers of inflammation associated with depression in in vitro and in vivo models of inflammation, neuroinflammation and depression. The ability of bioactive coffee constituents to modulate the parameters of neuroinflammation has been shown with caffeine having strong antioxidant properties in vitro, chlorogenic acid and caffeic acid having strong anti-inflammatory and antioxidant properties in vitro and ferulic acid having activities in in vivo animal models of depression.
咖啡是一种广泛饮用的饮品，含有众多主要属于多酚类和生物碱类的生物活性成分。已经证实，咖啡对包括抑郁症在内的多种疾病状态具有有益作用。一些前瞻性和回顾性队列研究评估了饮用咖啡对人类患重度抑郁症相对风险的影响。这些研究确定了饮用含咖啡因咖啡与患抑郁症风险之间存在负相关关系。咖啡因、绿原酸、阿魏酸和咖啡酸都是咖啡的重要成分，已显示它们具有的生物活性突出了与抑郁症病理可能存在的机制联系。本综述旨在评估在炎症、神经炎症和抑郁症的体外和体内模型中，对这些咖啡成分进行生物学评估所得证据，这些证据涉及与抑郁症相关的炎症标志物。生物活性咖啡成分调节神经炎症参数的能力已得到证实，其中咖啡因在体外具有强大的抗氧化特性，绿原酸和咖啡酸在体外具有强大的抗炎和抗氧化特性，阿魏酸在抑郁症的体内动物模型中具有活性。
