Stoller James K
Chair, Education Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail:
Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Cleve Clin J Med. 2016 Jul;83(7):507-14. doi: 10.3949/ccjm.83a.16031.
Alpha-1 antitrypsin deficiency is common but underrecognized. Because delayed diagnosis is thought to be associated with adverse outcomes, clinicians are encouraged to follow available guidelines and test for the disease in all symptomatic adults with fixed airflow obstruction. The weight of available evidence supports the biochemical and clinical efficacy of intravenous augmentation therapy. Promising new therapies are being investigated.
α-1抗胰蛋白酶缺乏症很常见，但却未得到充分认识。由于延迟诊断被认为与不良后果相关，因此鼓励临床医生遵循现有指南，对所有有固定气流受限症状的成年人进行该疾病的检测。现有证据支持静脉补充疗法的生化和临床疗效。目前正在研究有前景的新疗法。
