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慢性阻塞性肺疾病患者的α-1抗胰蛋白酶替代治疗

Alpha-1 Antitrypsin Replacement in Patients With COPD.

作者信息

Wells Adam D, Woods Anna, Hilleman Daniel E, Malesker Mark A

出版信息

P T. 2019 Jul;44(7):412-415.

PMID:31258312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6590928/
Abstract

Chronic obstructive pulmonary disease can be attributed to genetic conditions and predispositions, among other factors. Alpha-1 antitrypsin deficiency (AATD) is a significant risk factor for COPD development and progression, and aggressive screening for all patients with COPD or adult-onset asthma is encouraged.

摘要

慢性阻塞性肺疾病可归因于遗传状况和易感性等多种因素。α-1抗胰蛋白酶缺乏症(AATD)是慢性阻塞性肺疾病发生和进展的重要危险因素,因此鼓励对所有慢性阻塞性肺疾病患者或成年期发病的哮喘患者进行积极筛查。

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本文引用的文献

1
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Clin Liver Dis. 2018 Nov;22(4):643-655. doi: 10.1016/j.cld.2018.06.010. Epub 2018 Aug 22.
2
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Chest. 2018 Dec;154(6):1404-1415. doi: 10.1016/j.chest.2018.07.005. Epub 2018 Jul 17.
3
Underdiagnosis and Overdiagnosis of Chronic Obstructive Pulmonary Disease.慢性阻塞性肺疾病的漏诊和过度诊断。
Am J Respir Crit Care Med. 2018 Nov 1;198(9):1130-1139. doi: 10.1164/rccm.201804-0621CI.
4
Lessons from the Past: Some Histories of Alpha-1 Antitrypsin Deficiency Before Its Discovery.往昔之鉴:α-1抗胰蛋白酶缺乏症发现之前的一些历史
COPD. 2018 Feb;15(1):1-3. doi: 10.1080/15412555.2017.1421151.
5
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