Marom Shimon
Department of Physiology & Biophysics, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Curr Opin Neurobiol. 2016 Oct;40:66-71. doi: 10.1016/j.conb.2016.06.013. Epub 2016 Jul 9.
The capacity to generate action potentials in neurons and other excitable cells requires tuning of both ionic channel expression and kinetics in a large parameter space. Alongside studies that extend traditional focus on control-based regulation of structural parameters (channel densities), there is a budding interest in self-organization of kinetic parameters. In this picture, ionic channels are continually forced by activity in-and-out of a pool of states not available for the mechanism of excitability. The process, acting on expressed structure, provides a bed for generation of a spectrum of excitability modes. Driven by microscopic fluctuations over a broad range of temporal scales, self-organization of kinetic parameters enriches the concepts and tools used in the study of development of excitability.
神经元和其他可兴奋细胞产生动作电位的能力需要在一个大参数空间中对离子通道表达和动力学进行调节。除了传统上侧重于基于控制的结构参数（通道密度）调节的研究之外，人们对动力学参数的自组织也开始产生兴趣。在这种情况下，离子通道不断受到兴奋性机制不可用的状态池内外活动的驱动。该过程作用于表达的结构，为一系列兴奋性模式的产生提供了基础。在广泛的时间尺度上受微观波动驱动，动力学参数的自组织丰富了兴奋性发育研究中使用的概念和工具。
