米托蒽醌、环磷酰胺和长春新碱用于晚期乳腺癌的一线化疗。
First-line chemotherapy of advanced breast cancer with mitoxantrone, cyclophosphamide and vincristine.
作者信息
Bezwoda W R, Dansey R, Seymour L
机构信息
Department of Medicine, Haematology/Oncology, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
Oncology. 1989;46(4):208-11. doi: 10.1159/000226717.
Seventy-five patients with stage 4 breast cancer were treated with a first-line chemotherapy regimen consisting of cyclophosphamide 600 mg/m2, mitoxantrone 12 mg/m2, and vincristine 1.4 mg/m2 (CNV). Objective response was seen in 61/75 (81%) with 17/75 (23%) complete remission (CR). Median duration of response was 38 weeks overall and 51 weeks for patients achieving CR. CNV is an effective regimen for the treatment of advanced breast cancer.
75例IV期乳腺癌患者接受了由环磷酰胺600mg/m²、米托蒽醌12mg/m²和长春新碱1.4mg/m²组成的一线化疗方案（CNV）治疗。75例中有61例（81%）出现客观缓解，其中17例（23%）完全缓解（CR）。总体缓解持续时间中位数为38周，达到CR的患者为51周。CNV是治疗晚期乳腺癌的有效方案。
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