Iwamoto Taro, Fujimoto Masanori, Ikeda Kei, Saku Aiko, Makita Sohei, Furuta Shunsuke, Niewold Timothy B, Nakajima Hiroshi
a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
b Department of Immunology, Division of Rheumatology , Mayo Clinic , Rochester , MN , USA , and.
Mod Rheumatol. 2019 Jan;29(1):192-194. doi: 10.1080/14397595.2016.1205800. Epub 2016 Jul 12.
Clinical manifestations of systemic lupus erythematosus (SLE) in female patients with polysomy X have been less characterized as compared to those in male patients. Here, we describe a 28-year-old woman with trisomy X (47,XXX) who developed SLE. She had polyarthritis, hemolytic anemia, and was positive for anti-nuclear and anti-dsDNA antibodies. We discuss the common SLE manifestations with female polysomy X and the possible link between the development of SLE and the presence of extra X-chromosomes.
与男性患者相比，X染色体多体女性系统性红斑狼疮（SLE）患者的临床表现特征较少。在此，我们描述了一名患有X三体（47,XXX）并发生SLE的28岁女性。她有关节炎、溶血性贫血，抗核抗体和抗双链DNA抗体呈阳性。我们讨论了X染色体多体女性的常见SLE表现以及SLE发生与额外X染色体存在之间的可能联系。
