小气道在哮喘中的作用。

Role of Small Airways in Asthma.

作者信息

Finkas Lindsay K, Martin Richard

机构信息

Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.

Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.

出版信息

Immunol Allergy Clin North Am. 2016 Aug;36(3):473-82. doi: 10.1016/j.iac.2016.03.009.

DOI:10.1016/j.iac.2016.03.009

PMID:27401620

Abstract

Asthma is an inflammatory condition of both the small and large airways. Recently the small airways have gained attention as studies have shown significant inflammation in the small airways in all severities of asthma. This inflammation has correlated with peripheral airway resistance and as a result, noninvasive methods to reliably measure small airways have been pursued. In addition, recent changes in asthma inhalers have led to alterations in drug formulations and the development of extrafine particle inhalers that improve delivery to the distal airways.

摘要

哮喘是一种大小气道的炎症性疾病。最近，小气道受到了关注，因为研究表明，在所有严重程度的哮喘中，小气道都存在显著炎症。这种炎症与外周气道阻力相关，因此人们一直在寻求可靠测量小气道的非侵入性方法。此外，哮喘吸入器最近的变化导致了药物制剂的改变以及超细颗粒吸入器的开发，这些吸入器能改善药物向远端气道的递送。