Putcha Nirupama, Wise Robert A
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, JHAAC 4B.74, Baltimore, MD 21224, USA.
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, JHAAC 4B.74, Baltimore, MD 21224, USA.
Immunol Allergy Clin North Am. 2016 Aug;36(3):515-28. doi: 10.1016/j.iac.2016.03.003.
The debate about whether asthma and chronic obstructive pulmonary disease (COPD) are distinct clinical syndromes is not new; there is heightened interest in understanding the group of individuals with obstructive lung disease who seem to have elements of both conditions because recent studies have demonstrated increased risk for respiratory events and exacerbations. We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma-COPD overlap category. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways.
关于哮喘和慢性阻塞性肺疾病（COPD）是否为不同临床综合征的争论并不新鲜；对于了解患有阻塞性肺病且似乎兼具这两种疾病特征的个体群体，人们的兴趣日益浓厚，因为最近的研究表明这些个体发生呼吸事件和病情加重的风险增加。我们描述了这种疾病亚型的临床特征，并提出了4种适用于哮喘-COPD重叠类型个体的工作定义。了解这些亚型背后的机制有望促成对能够针对特定病理生物学途径的治疗策略的更好理解。
